OECD 210, OPPTS/OCSPP 850.14
This study is intended to define the lethal and sub-lethal effects of chemicals on the early life stages of the species tested.
The early-life stages of fish are exposed to at least five concentrations of the test substance dissolved in water, typically under flow-through conditions, or where appropriate, semi-static conditions. The test starts with placing fertilised eggs (at least 60) in the test chambers and continues at least until all the control fishes are free-feeding.
Lethal and sub-lethal effects are assessed and compared with control values to determine the lowest observed effect concentration and the no observed effect concentration.
The study report includes measurement of the concentrations of the test substance in water at regular intervals (five at least), the dissolved oxygen, pH, total hardness and salinity, fish weight and length, as well as the observations of abnormal appearance, abnormal behaviour, hatching and survival.
Vertebrate, Chronic, Marine, Freshwater.
OECD (2013), Test No. 210: Fish, Early-life Stage Toxicity Test, OECD Guidelines for the Testing of Chemicals, Section 2, OECD Publishing, Paris, https://doi.org/10.1787/9789264203785-en.
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